Ling Qi
Assistant Professor

 Ling Qi

Phone

607-254-8857 (office) and 255-6169 (lab)
Fax: (607) 255-6249 and -1033 Fax: 607 255-1033

Address

Division of Nutrition
445 Biotechnology Building
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

 Department Profile

Overview

 Unfolding the unfolded protein response (UPR): We are interested in transcription regulation of UPR in the context of the so-called "conformational diseases" such as diabetes, obesity, cancer, and neurodegenerative diseases.  The questions we address in particular are: what is the physiological role of UPR in type II diabetes and obesity?  how do other signaling pathways regulate UPR?  We use biochemical, genetic, immunological and high throughput approaches in both mouse- and cell culture-models to address these fundamental questions.

Our laboratory aims to bring a standard excellence to what we do as individuals and as a laboratory.  We strive to create an environment that is fair, respectful, collegial and conducive to new ideas.  We welcome highly self-motivated individuals (postdoctoral fellows, graduate and undergraduate students) to join us.  Please feel free to visit us (Rm. 445 of the Biotechnology Building, Cornell University)

Selected Publications

Qi, L.*, Heredia, J.*, Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., MacLeod, I.X., Liew, C.W., Kulkarni, R., Bain, J., Nelson, M., Evans, R.M., Yates, J., and Montminy, M. 2006. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 312: 1763-6 (*, contribute equally)

Koo, S.H.*, Flechner, L.*, Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., and Montminy, M. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 437: 1109-15 (*, contribute equally)

Qi, L., Strong, M.A., Karim, B.O., Huso, D.L., and Greider, C.W. 2005. Telomere fusion to chromosome breaks reduces oncogenic translocations and tumor formation. Nature Cell Biology. 7: 706-11.

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